the psychological state of being irritated or annoyedいらいらする、あるいはむしゃくしゃする精神的状態苛苛
something or someone that causes trouble; a source of unhappiness; "washing dishes was a nuisance before we got a dish washer"; "a bit of a bother"; "he's not a friend, he's an infliction"問題を起こす物、あるいは人邪魔